Endocrine Abstracts

Insulin degludec (IDeg) is an ultra-long-acting basal insulin that forms soluble multi-hexamers after injection. These release monomers slowly and continuously to produce a flat and stable glucose-lowering effect. We describe the pharmacokinetic and pharmacodynamic properties of IDeg compared with insulin glargine (IGlar) under steady-state conditions in patients with type 1 diabetes (T1D). This was a randomised, double-blind, two-period crossover study in 66 patients with T1D...